Erika Pearce How Does Metabolism Influence the Function of Different T Cell Types?
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The Max Planck Institute of Immunobiology and Epigenetics (MPI-IE) in Freiburg is an interdisciplinary research institution that conducts basic research in two key areas of modern biology. Immunobiology is concerned with the ways multicellular organisms defend themselves against pathogens. We study the evolutionary origins and the development of lymphoid organs and immune effector cells, the function of antigen receptors, and the genetic basis of host-pathogen interactions. This information underpins efforts to better diagnose and treat immunodeficiency and inflammatory diseases.
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T cells are an important component of the body’s immune system. As ERIKA PEARCE explains, there are several types of T cells which form consecutively during the immune response and serve different purposes. Effector T cells combat pathogens from infections or tumors while memory T cells provide protective immunity to prevent re-infection or reoccurring cancer. The research presented in this video investigates how the metabolism of the T cells influences the development of effector and memory T cells by blending in vitro and in vivo approaches. The findings show that the morphology of the mitochondria determines the ability of different types of T cells to perform their functions. Furthermore, the researchers were able to modify the mitochondria in a way that the resulting T cells would provide a better immunity against cancer. These insights open up new possibilities to alter immune cell function and thus might lead to improved immunotherapy.
LT Video Publication DOI: https://doi.org/10.21036/LTPUB10372
Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming
- Michael D. Buck, David O’Sullivan, Ramon I. Klein Geltink, Jonathan D. Curtis, Chih-Hao Chang, David E. Sanin, Jing Qiu, Oliver Kretz, Daniel Braas, Gerritje J. W. van der Windt and Erika Pearce
- Published in 2016