Stefan H. E. Kaufmann Can Biosignatures Be Used to Develop a Reliable, Fast and Low-Cost Test for Tuberculosis?
© Maximilian Dörrbecker
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Tuberculosis is still a major health issue and the number one killer of all contagious diseases. But while more than 2 billion people are infected with the tuberculosis agent, only 10% develop an active disease. Current diagnostic tests cannot distinguish between infected people and people with active tuberculosis. In this video, STEFAN H. E. KAUFMANN explains that they found a characteristic gene expression profile of people infected with tuberculosis. Relying on only four markers they developed a highly sensitive method that is not only able to identify people with active tuberculosis but is also suitable for point of care application in countries with low resources.
LT Video Publication DOI: http://dx.doi.org/10.21036/LTPUB10210
Concise Gene Signature for Point-Of-Care Classification of Tuberculosis
- Jeroen Maertzdorf, Gayle McEwen, January Weiner, Song Tian, Eric Lader, Ulrich Schriek, Harriet Mayanja-Kizza, Martin Ota, John Kenneth and Stefan H.E. Kaufmann
- EMBO Molecular Medicine
- Published in 2015