Franziska Jundt Is Physical Activity an Effective Treatment for Bone Cancer?
University of Würzburg (Julius-Maximilians-Universität Würzburg)Würzburg, Germany
"True to its motto ‘Science for Society’, the Julius-Maximilians-Universität Würzburg (JMU) - founded 1402 - is committed to advancing research in a wide range of disciplines. Academic rankings confirm the JMU’s place among the world’s high-performing research universities. Currently, the JMU has about 29.000 students who are enrolled in ten faculties. Its academic and administrative staff comprises more than 4.000 people. Approximately 420 professors are active in research and teaching at the university and the university hospital.
High-quality medical care and cutting-edge research
The University Hospital of Würzburg consists of 19 clinics with policlinics and three autonomous policlinics as well as four clinical institutes. About 74.000 stationary and 270.000 ambulant patients have been taken care of per annum (2019). In addition the interdisciplinary cooperation in clinical centers, for example in the Comprehensive Cancer Center Mainfranken, takes center stage.
Current pharmacological treatments for bone cancers like multiple myeloma have proven ineffective at healing bones or regenerating bone tissue. In this video, FRANZISKA JUNDT explores the extent to which physical stimuli and physical activity could represent effective treatment strategies for such conditions. Jundt explains how work with mice infected with tumor cells was followed up by a pilot clinical study on patients with a precursor condition to multiple myeloma, monoclonal gammopathy of undetermined significance. The work demonstrates that physical stimuli can have anti-tumor effects and it provides a scientific basis for a targeted use of sports against bone cancer. Ongoing research will analyze how physical activity has an effect on bone at the genetic level.
LT Video Publication DOI: https://doi.org/10.21036/LTPUB10897
Mechanical Loading Prevents Bone Destruction and Exerts Anti-Tumor Effects in the MOPC315.BM.Luc Model of Myeloma Bone Disease
- Maximilian Rummler*, Fani Ziouti*, Alice L. Bouchard, Andreas Brandl, Georg N. Duda, Bjarne Bogen, Andreas Beilhack, Maureen E. Lynch, Franziska Jundt* and Bettina M. Willie*
- (*These authors contributed equally) Acta Biomaterialia.
- Published in 2020
Impact of Whole-Body Vibration Exercise on Physical Performance and Bone Turnover in Patients with Monoclonal Gammopathy of Undetermined Significance
- Lothar Seefried, Franca Genest, Johanna Strömsdörfer, Bernhard Engelmann, Constantin Lapa, Franz Jakob, Freerk T. Baumann, Billy Sperlich and Franziska Jundt
- Journal of Bone Oncology
- Published in 2020