Laura De Laporte How Can Biomaterial Scaffolds Help to Repair Damaged Spinal Cords by Guiding Nerves to Grow Across the Injury?

Laura De Laporte is a Junior Research Group Leader at the Leibniz Institute for Interactive Materials, at RWTH Aachen University, Germany. Her fields of expertise are biotechnology, biomaterials, and animal surgery. In 2009, De Laporte received her PhD from Northwestern University, working on the use of biomaterials in the field of tissue engineering. More specifically, De Laporte examined post-injury spinal chord regeneration. In her current research project, De Laporte continues to work on this topic, looking at how biomaterial scaffolds can be developed to aid the regenerative process.

Area of Research

Chemical and Biomedical Engineering

Jose Guillermo Torres-Rendon, Marius Köpf, David Gehlen, Andreas Blaeser, Horst Fischer, Laura De Laporte and Andreas Walther. "Cellulose Nanofibril Hydrogel Tubes as Sacrificial Templates for Freestanding Tubular Cell Constructs." Biomacromolecules 17 (2016): 905-913.  
Laura De Laporte, Jeffrey J. Rice, Federico Tortelli and Jeffrey A. Hubbell. "Tenascin C Promiscuously Binds Growth Factors via its Fifth Fibronectin Type III-Like Domain." PloS One 8 (2013): e62076.  
Laura De Laporte, Anna Lei Yan and Lonnie D. Shea. "Local Gene Delivery from ECM-Coated Poly (Lactide-Co-Glycolide) Multiple Channel Bridges After Spinal Cord Injury." Biomaterials 30 (2009): 2361-2368.  
Jeffrey J. Rice, Mikaël M. Martino, Laura De Laporte, Federico Tortelli, Priscilla S. Briquez and Jeffrey A. Hubbell. "Engineering the Regenerative Microenvironment with Biomaterials." Advanced Healthcare Materials 2 (2013): 57-71.  

since 2013

Junior Research Group Leader

DWI – Leibniz Institute for Interactive Materials (more details)

And RWTH Aachen University

2009-2012

Postdoctoral Research Fellow

Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland

2003-2004

Research Assistant

Northwestern University, Illinois

Department of Chemical and Biological Engineering

2009

PhD

Northwestern University, Illinois

Thesis "Multiple Channel Bridges with the Ability for DNA and Protein Delivery for Spinal Cord Regeneration"

2003

Master in Chemical Engineering

University of Ghent

Thesis "Development of a Cardiovascular Flow Model and Drug-Eluting Stents Applications"

Fellowships

Terminal Year Richter Fellowship, NU (2008-2009)

AIChE Women's Initiatives Committee Travel Award, USA (2008)

Conference Travel Grant, NU (Per Year) (2006, 2007, 2008)

CGM Travel Fellowship Award, USA (2006)

International Fellowship, NU (2004-2005)

ERC Starting Grant – ANISOGEL (2015–2020)

DFG Nachwuchsakademie MatWerk (2015–2017)

Marie Curie ITN – BIOGEL (2015–2018)

Umbrella Seed Fund RWTH with Avi Schröder (2015–2016)

Dean’s Seed Fund – Fakultät 1 with Angela Lampert (2016)

Ramp-Up Project SFB985 (2014–2015)

© Carpus+Partner/Jörg Stanzick

DWI – Leibniz Institute for Interactive Materials


Research at DWI – Leibniz-Institut für Interaktive Materialien e.V. (DWI – Leibniz Institute for Interactive Materials) focuses on the development of materials with active and adaptive properties, after being founded in 1952 with an original emphasis on keratin research and protein chemistry. The capability for active adaptation and interactivity is one of the most profound challenges of today’s materials research and will ultimately lead to the evolution of structural via functional to intelligent materials. At DWI scientists with backgrounds in polymer sciences, biotechnology and chemical engineering closely collaborate on mastering this challenge.

The research approach at DWI is based on integrating molecular components, whose structure and dynamics are orchestrated by complex interactions on various length scales, into macroscopic materials, devices and in the end systems. For exceeding the passive functionalities of existing materials, DWI researches on switchable material properties, the application of memory effects, the integration of energy conversion systems, as well as on internal feedback mechanisms. Beyond materials aspects the DWI team aims at an integration of active characteristics into interacting material systems. The fields of application are diverse, dealing with surface finishing, biomedical technology, biotechnology and sustainable chemical engineering. (Source)

Map

In the 1980s researchers showed that damaged nerves in the spinal cord have the ability to regrow. Chemical engineers contribute to the field of spinal cord repair by developing biomaterial scaffolds that support cell and nerve growth inside the body after an injury. In the research project explained by LAURA DE LAPORTE in this video, such scaffolds were developed and tested: The special architecture of the developed structures uses oriented channels to guide the nerves to grow across the site of injury. Moreover, delivering DNA via the scaffolds resulted in growth of specific proteins that further stimulated the nerve cells to grow. The research project shows that the developed scaffolds can be used twofold: As an architecture, a physical help for the nerves to grow, but also to deliver significant crucial growth factors that are necessary to further stimulate spinal cord repair.

LT Video Publication DOI: https://doi.org/10.21036/LTPUB10192

Plasmid Releasing Multiple Channel Bridges for Transgene Expression after Spinal Cord Injury

  • Laura De Laporte, Yang Yang, Marina L. Zelivyanskaya, Brian J. Cummings, Aileen J. Anderson and Lonnie D. Shea
  • Molecular Therapy
  • Published in 2009

Chicago

Laura De Laporte, Yang Yang, Marina L. Zelivyanskaya, Brian J. Cummings, Aileen J. Anderson and Lonnie D. Shea. "Plasmid Releasing Multiple Channel Bridges for Transgene Expression after Spinal Cord Injury." Molecular Therapy 17 (2009): 318-326.