Scroll to Section:

Sepsis is a common disease in intensive care. Under this condition the body reacts to infection by injuring its own tissues and organs which leads to high mortality rates. Until now reliable methods to identify vulnerable patients are lacking, and treatment is mainly directed at its symptoms. The research presented in this video focuses on endothelial progenitor cells, a cell type derived from the bone marrow circulating in the bloodstream. Their role in the development and healing of sepsis is examined. In order to quantify the endothelial progenitor cells the study uses flow cytometry – a biotechnological method to sort and count cells. The findings indicate that VEGF, the vascular endothelial growth factor, correlates with a positive outcome of the disease. These results specifying the role of endothelial progenitor cells can lead to new therapies for sepsis and may in the future also help to cure various diseases such as diabetes or strokes by supporting endothelial regeneration of the body itself.
DOI:
https://doi.org/10.21036/LTPUB10066
Tags:

Researcher

Neysan Rafat is a doctor at the University Clinic Heidelberg, Germany. He specializes in Pediatrics, Nephrology, and Emergency Medicine. In 2009, Rafat won the Young Investigator Award of the Medical Faculty Heidelberg, followed by the Fokko van der Woude Research Grant of the German Kidney Foundation in 2010.

In his current research, Rafat focuses on the course of a Sepsis, reviewing the research done and exploring further research that could help move the knowledge on Sepsis.

Institution

Heidelberg University (Ruprecht-Karls-Universität Heidelberg)

"Heidelberg University, founded in 1386, is Germany’s oldest university and one of the strongest research universities in all of Europe. The successes in both rounds of the Excellence Initiative and in internationally recognised rankings prove that Heidelberg’s excellent reputation and leading role in the scientific community are well deserved. In terms of educating students and promoting promising early-career academics, Heidelberg relies on research-based teaching and an outstanding, well-structured training for doctoral candidates. Heidelberg University is a comprehensive university, offering the full spectrum of disciplines in the humanities, law and the social sciences alongside the natural and life sciences, including medicine. As a comprehensive university, Heidelberg aims to continue to strengthen the individual disciplines and to further interdisciplinary cooperation, as well as to carry research results over into society and industry. With its aspiration of connecting traditional values with future-oriented scientific concepts in research and teaching, the university is building bridges to the future – Zukunft. Seit 1386." ( Source )
Show more

Original publication

Increased Circulating Endothelial Progenitor Cells in Septic Patients: Correlation with Survival

Rafat Neysan, Hanusch Christine, Brinkkoetter Paul T., Schulte Jutta, Brade Joachim, Zijlstra Jan G., van der Woude Fokko J., van Ackern Klaus, Yard Benito A. and Beck Grietje Ch.
Critical Care Medicine
Published in 2007

Reading recommendations

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

Asahara Takayuki, Murohara Toyoaki, Sullivan Alison, Silver Marcy, van der Zee Rien, Li Tong, Witzenbichler Bernhard, Schatteman Gina and Isner Jeffrey M.
Science
Published in 1997

Endothelial Progenitor Cells for Postnatal Vasculogenesis

Asahara Takayuki and Kawamoto Atsuhiko
American Journal of Physiology-Cell Physiology
Published in 2004

Endothelial Progenitor Cells and a Stromal Cell-Derived Factor-1Alpha Analogue Synergistically Improve Survival in Sepsis

Fan Hongkuan, Goodwin Andrew J., Chang Eugene, Zingarelli Basilia, Borg Keith, Guan Shuwen, Halushka Perry V. and Cook James A.
American Journal of Respiratory and Critical Care Medicine
Published in 2014

Monitoring of Endothelial Dysfunction in Critically ill Patients: The Role of Endothelial Progenitor Cells

Cribbs Sushma K., Martin Greg S. and Rojas Mauricio
Current Opinion in Critical Care
Published in 2008

Circulating Endothelial Progenitor Cells Inversely Associate with Organ Dysfunction in Sepsis

Cribbs Sushma K., Martin Greg S., Rojas Mauricio, Sutcliffe Diane J., Taylor William R., Easley Kirk A., Tang Li and Brigham Kenneth L.
Intensive Care Medicine
Published in 2012
Show more

Beyond