Volker Haucke How Does The Recycling Process Within Eukaryotic Cells Work on a Molecular Level?
Leibniz Institute for Molecular Pharmacology (FMP)
The FMP conducts basic research in Molecular Pharmacology with the aim to identify novel bioactive molecules and to characterize their interactions with their biological targets in cells or organisms. These compounds are useful tools in basic biomedical research and may be further developed for the treatment, prevention, or diagnosis of disease.
To this aim FMP researchers study key biological processes and corresponding diseases, such as cancer, aging including osteoporosis, or neurodegeneration. They also develop and apply advanced technologies ranging from screening technologies over NMR based methods to proteomics and in vivo models. (Source: FMP)
Department of Molecular Pharmacology and Cell Biology
The focus of research in the Haucke laboratory is the dissection of the molecular mechanisms of endocytosis and endolysosomal membrane dynamics and its role in cell signaling and neurotransmission. The laboratory uses a wide range of technologies that include biochemical and molecular biological approaches in vitro, chemical biology and screening technology, super-resolution and electron microscopy as well as genetic manipulations at the organismic level in vivo. The overarching goal of these studies is to provide a mechanistic understanding of exo-endocytosis and endolysosomal function and its regulation by proteins and lipids and to use this know-how to develop novel strategies for acute chemical and pharmacological interference. (Source)
The research presented in the video investigates how endosomes are able to transport material back to the cell surface in a process called recycling or endosomal exocytosis. In order to do so, endosomes have to have their own identity which is defined by a phosphoinositide, Phosphatidylinositol 3-phosphate (PI3P). To deliver the material to the cell surface the endosomes have to get rid of their old PI3P identity and acquire a new identity that is characteristic of the plasma membrane such as PI4-phosphate (PI4P). VOLKER HAUCKE explains that understanding how this conversion of phosphoitnositide identities occurs is important to understand communication within a cell and how it may be related to diseases.
LT Video Publication DOI: http://dx.doi.org/10.21036/LTPUB10330
A Phosphoinositide Conversion Mechanism for Exit from Endosomes
- Katharina Ketel, Michael Krauss, Anne-Sophie Nicot, Dmytro Puchkov, Marnix Wieffer, Rainer Müller, Devaraj Subramanian, Carsten Schultz, Jocelyn Laporte and Volker Haucke
- Published in 2016