Sven Diederichs Which Functions Do the Noncoding Parts of Human RNA Have in Metastasis Formation of Lung Cancer Cells?
© Sandra Meyndt/University of Freiburg
Albert Ludwigs University of Freiburg (Albert-Ludwigs-Universität Freiburg)
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Parts of the human RNA that are not translated into proteins may still have an important function. As SVEN DIEDERICHS explains in this video, the occurrence of the RNA gene Malat-1 makes the difference between lung cancer with and without metastasis. By first identifying Malat-1 as the molecular difference between patients and then silencing this RNA gene, it was found that Malat-1 could be a viable target to suppress development of metastasis in lung cancer therapy.
LT Video Publication DOI: http://dx.doi.org/10.21036/LTPUB10072
The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
- Tony Gutschner, Monika Hämmerle, Moritz Eißmann, Jeff Hsu, Youngsoo Kim, Gene Hung, Alexey Revenko, Gayatri Arun, Marion Stentrup, Matthias Groß, Martin Zörnig, A. Robert MacLeod, David L. Spector et al
- Cancer Research
- Published in 2013
MALAT-1, a Novel Noncoding RNA, and Thymosin β4 Predict Metastasis and Survival in Early-Stage Non-Small Cell Lung Cancer
- Ping Ji, Sven Diederichs, Wenbing Wang, Sebastian Böing, Ralf Metzger, Paul M. Schneider, Nicola Tidow, Burkhard Brandt, Horst Buerger, Etmar Bulk, Michael Thomas, Wolfgang E. Berdel, Hubert Serve et al
- Published in 2003
Noncoding RNA Gene Silencing Through Genomic Integration of RNA Destabilizing Elements Using Zinc Finger Nucleases
- Tony Gutschner, Marion Baas and Sven Diederichs
- Genome Research
- Published in 2011