Sven Diederichs Which Functions Do the Noncoding Parts of Human RNA Have in Metastasis Formation of Lung Cancer Cells?

Sven Diederichs is Group Leader of the division ‘Cancer Research’ at the Clinic for Thoracic Surgery, at the Albert-Ludwigs-University Freiburg, Germany. Diederichs spent three years (2005-2008) as a postdoctoral fellow at Harvard Medical School, working at the Massachusetts General Hospital Cancer Centre. For his research on cancer, Diederichs was awarded several prizes, including the 2014 Liver Cancer Research Award of the German Society for Gastrointestinal Diseases and Bayer Health Care and the Dr. Hella Bühler Prize in 2013. Diederichs’ specific interest lies in how the RNA gene Malat-1 can determine the occurrence of lung cancer with or without metastasis.

Area of Research

Molecular Biology: Cancer Research, RNA Biology

Monika Hämmerle, Tony Gutschner, Hannah Uckelmann, Sevim Ozgur, Evgenij Fiskin, Matthias Gross, Britta Skawran, Robert Geffers, Thomas Longerich, Kai Breuhahn, Peter Schirmacher, Georg Stoecklin and Sven Diederichs. "Post-Transcriptional Destabilization of the Liver-Specific Long Non-Coding RNA HULC by the IGF2 mRNA-Binding Protein 1 (IGF2BP1)." Hepatology 58 (2013): 1703-1712.  
Julia Winter, Stephanie Jung, Sarina Keller, Richard I. Gregory and Sven Diederichs. "Many Roads to Maturity: MicroRNA Biogenesis Pathways and their Regulation." Nature Cell Biology 11 (2009): 228-234.  
Sven Diederichs and Daniel A. Haber. "Dual Role for Argonautes in MicroRNA Processing and Posttranscriptional Regulation of MicroRNA Expression." Cell 131 (2007): 1097-1108.  

since 2016

Full Professor Division Head of the Division "Cancer Research"

Albert Ludwigs University of Freiburg (Albert-Ludwigs-Universität Freiburg) (more details)

Clinic for Thoracic Surgery, University Hospital Freiburg

since 2015

Division Head

German Cancer Research Center (DKFZ)

Of the Division "RNA Biology & Cancer"

2009-2014

Junior Group Leader of the Helmholtz-University-Junior Research Group

German Cancer Research Center (DKFZ)

And the Institute of Pathology, University of Heidelberg

2008-2014

Junior Group Leader

German Cancer Research Center (DKFZ)

2005-2008

Postdoctoral Fellow

Laboratory of Prof. Dr. Daniel A. Haber, Harvard Medical School/Massachusetts General Hospital Cancer Center, Boston

2004

PhD in Molecular Biology (Hematology/Ontology)

University of Münster (Westfälische Wilhelms-Universität Münster)

And the University of Witten/Herdecke

2002

Diploma in Biochemistry

University of Münster (Westfälische Wilhelms-Universität Münster)

Department of Medicine, Hematology/Oncology

American Association for Cancer Research (AACR) (since 2003)

GBM Study Group RNA Biochemistry (since 2006)

German Society for Biochemistry & Molecular Biology (GBM) (since 2006)

German Society for Pathology (DGP) (since 2010)

RNA Society (since 2007)

Prizes

Liver Cancer Research Award of the German Society for Gastrointestinal Diseases (DGVS) & Bayer Health Care (2014)

Binder Innovation Prize of the German Society of Cell Biology (DGZ) (2012)

Karl-Freudenberg-Preis of the Heidelberg Academy of Sciences and Humanities (2010)

Presentation Award Miami Winter Symposium “Regulatory RNA in Biology and Human Health” (2008)

Scholar-in-Training Award of the American Association for Cancer Research (AACR): “The Role of Non-Coding RNAs in Cancer” (2007)

Young Investigator Award of the German Academy of Scientists Leopoldina (2005)

PhD Thesis Award of the German Society for Hematology and Oncology (DGHO) (2005)

Scholar-in-Training Award of the American Association for Cancer Research (AACR) / Pezcoller Foundation (2003)

Fellowships

Member of "Die Junge Akademie" (2010-2015)

PhD Scholarship Award of the German Academic Merit Foundation (Studienstiftung des deutschen Volkes) (2002-2004)

Scholarship Award of the German Academic Merit Foundation (Studienstiftung des deutschen Volkes) (1997-2001)

Member of the Selection Committee for the German Academic Merit Foundation (Studienstiftung des deutschen Volkes)

Group Leader "Genetics & Genomics" in the Life Science College of the German Academic Merit Foundation (Studienstiftung des deutschen Volkes)

Dr. Hella Bühler Prize for Cancer Research (2013)

© Sandra Meyndt/University of Freiburg

Albert Ludwigs University of Freiburg (Albert-Ludwigs-Universität Freiburg)


Founded in the 15th century, the University of Freiburg has a long-standing reputation of excellence in academic teaching and research. Among the most renowned university members were the philosophers Edmund Husserl and Martin Heidegger, the economist Walter Eucken, and such Nobel Prize winners as Hans Spemann, Hermann Staudinger, Georg von Hevesy, Friedrich August von Hayek and George Köhler. Today, with its mixture of traditional subjects and modern technology, the University of Freiburg is flourishing more than ever. The university and its hospital employ more than 19,000 staff members. Organized according to the classical model of a comprehensive university, it provides 25,000 students with a broad range of subjects – from applied information technology, the entire spectrum of medical specialities and natural sciences to the fields of humanities and social sciences. Freiburg’s research and teaching policies aim to overcome the barriers between individual disciplines to create opportunities for new perspectives on complex problems. By supporting collaborative research projects across boundaries and implementing centers of knowledge and interdisciplinary graduate colleges, the university provides the disciplines an effective means by which to benefit from each other’s knowledge.

An added benefit that comes with such flexibility is an increased international interest for our university: We are pleased to have a significant number of scientists and students from all over the world, whose culture-specific views of scientific procedures and research approaches enrich the dialog with their German counterparts. 16% of the student body are from foreign countries. The general international exchange of scientific results and experiences also plays an important role at the University of Freiburg. More than 300 partner universities and programs on five continents, together with the alumni association, form a first-class international network. (Source: University of Freiburg)

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Parts of the human RNA that are not translated into proteins may still have an important function. As SVEN DIEDERICHS explains in this video, the occurrence of the RNA gene Malat-1 makes the difference between lung cancer with and without metastasis. By first identifying Malat-1 as the molecular difference between patients and then silencing this RNA gene, it was found that Malat-1 could be a viable target to suppress development of metastasis in lung cancer therapy.

LT Video Publication DOI: https://doi.org/10.21036/LTPUB10072

The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells

  • Tony Gutschner, Monika Hämmerle, Moritz Eißmann, Jeff Hsu, Youngsoo Kim, Gene Hung, Alexey Revenko, Gayatri Arun, Marion Stentrup, Matthias Groß, Martin Zörnig, A. Robert MacLeod, David L. Spector et al
  • Cancer Research
  • Published in 2013

Chicago

Tony Gutschner, Monika Hämmerle, Moritz Eißmann, Jeff Hsu, Youngsoo Kim, Gene Hung, Alexey Revenko, Gayatri Arun, Marion Stentrup, Matthias Groß, Martin Zörnig, A. Robert MacLeod, David L. Spector et al. "The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells." Cancer Research 73 (2013): 1180-1189.

MALAT-1, a Novel Noncoding RNA, and Thymosin β4 Predict Metastasis and Survival in Early-Stage Non-Small Cell Lung Cancer

  • Ping Ji, Sven Diederichs, Wenbing Wang, Sebastian Böing, Ralf Metzger, Paul M. Schneider, Nicola Tidow, Burkhard Brandt, Horst Buerger, Etmar Bulk, Michael Thomas, Wolfgang E. Berdel, Hubert Serve et al
  • Oncogene
  • Published in 2003

Chicago

Ping Ji, Sven Diederichs, Wenbing Wang, Sebastian Böing, Ralf Metzger, Paul M. Schneider, Nicola Tidow, Burkhard Brandt, Horst Buerger, Etmar Bulk, Michael Thomas, Wolfgang E. Berdel, Hubert Serve et al. "MALAT-1, a Novel Noncoding RNA, and Thymosin β4 Predict Metastasis and Survival in Early-Stage Non-Small Cell Lung Cancer." Oncogene 22 (2003): 8031-8041.

Noncoding RNA Gene Silencing Through Genomic Integration of RNA Destabilizing Elements Using Zinc Finger Nucleases

  • Tony Gutschner, Marion Baas and Sven Diederichs
  • Genome Research
  • Published in 2011

Chicago

Tony Gutschner, Marion Baas and Sven Diederichs. "Noncoding RNA Gene Silencing Through Genomic Integration of RNA Destabilizing Elements Using Zinc Finger Nucleases." Genome Research 21 (2011): 1944-1954.